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The 5 Best Gluten-Free Italian Restaurants in Downtown

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By Gluten Free Eats' gluten-free community

Updated May 2025

01
Osteria 166

Osteria 166

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166 Franklin St, Buffalo, NY 14202, USA

GF OptionsItalianPizzaDinnerLunchOutdoor SeatingTake AwayVegetarian OptionsVegan OptionsBread ItemsPastaSandwichesBrunchOpen LateDeliveryKid FriendlyRestaurant
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Amazing food, great service, and many gluten free options (pasta, pizza, etc.) The waitstaff was very knowledgeable on allergies and celiac disease and made sure to accommodate everyone. Plus, the food was absolutely amazing.

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02
Pizza Plant Italian Pub - Canalside

Pizza Plant Italian Pub - Canalside

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125 Main St #110, Buffalo, NY 14203, USA

LunchVeganItalianDeliveryTake AwayKid FriendlyVegetarianBarOutdoor Seating
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The Server was very sweet but the food.. The gluten-free pizza was Horrible. I couldn’t even finish 1 slice, also Cost me $30! Was not worth it. I didnt want to make a fuss about it since I had my son with me,so I just sucked it up didn’t say anything. The normal pizza was fine just pizza nothing special.

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03
JJs Casa Di Pizza

JJs Casa Di Pizza

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11 E Mohawk St, Buffalo, NY 14203, USA

LunchDinnerOpen LateItalianPizzaDeliveryTake AwayOutdoor SeatingKid FriendlyBread ItemsBar
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Donna Backshall

Very much a locals spot. For gluten-free diners, please know there are multiple safe options, including gf wings. However, the gf pizza crust is cauliflower, so if you cannot tolerate this, like me, please order accordingly. The menu does not specify.

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04
Frankie Primo's +39

Frankie Primo's +39

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51 W Chippewa St, Buffalo, NY 14202, USA

LunchDinnerBrunchOpen LateItalianTake AwayOutdoor SeatingKid FriendlyRestaurant
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Connor Siem

They have gluten free options which always helps so celiac friendly! Tortellini soup was amazing and the pizza was solid.

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05
Blue Cave Italian Restaurant

Blue Cave Italian Restaurant

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128 Genesee St, Buffalo, NY 14203, USA

DinnerItalianDeliveryTake AwayOutdoor SeatingKid FriendlyRestaurant
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How it is Liz

A great night at Blue Cave, one of downtown Buffalo's new restaurants! We felt extremely welcome from the moment we walked in the door. The staff is very attentive and seemed to be enjoying their jobs! We were seated promptly upstairs. This is an Italian restaurant. However, we did feel more of a Greek, Santorini type vibe from the decor and overall atmosphere. It really didn't matter because everything we ordered was very enjoyable. Our drinks were good, especially their specialty apple cider mule. For appetizers, we ordered the Panelle chickpea fritters and the Caponata fried eggplant. The two complimented each other well. Next came our second course, the salads. We ordered the Mediterranea and Misticanza. The fried artichokes were a fantastic topping on the mixed greens! Finally, for our main entree, we both chose the seabass listed on the menu with a side of truffle mashed potatoes and asparagus. The seabass was Italian branzino that was cooked and steamed in a parchment bag . Large flavorful portions. They have lots of healthy options and gluten-free pasta available, too. The chef, who I think may also be the owner, is very talented and really knows how to cook!! Definitely make a stop out to support this local business. You won't be disappointed!

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