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The 24 Best Gluten-Free Sandwich Spots in Iowa

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By Gluten Free Eats' gluten-free community

Updated Jul 2025

01
Destination Grille

Destination Grille

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Celiac friendly

2491 E 1st St, Grimes, IA 50111, USA

AmericanBrunchCeliac FriendlyPizzaGF OptionsBurgersDairy Free OptionsDinnerOpen Late NightLunchTake AwayVegetarian OptionsVegan OptionsKnowledgeable StaffDedicated GF FryerBread ItemsFriesSandwichesBreakfastDeliveryOutdoor SeatingKid FriendlyPet Friendly
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Natalie Clark

I highly recommend any of the burgers, pizzas, and especially the chicken tenders. LOVE

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02
Club Car Restaurant & Lounge

Club Car Restaurant & Lounge

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Accommodating

13435 University Ave #200, Clive, IA 50325, USA

ItalianRestaurantGF OptionsBurgersLocal CuisineAmericanTeaTake AwayIndoor SeatingHealth FoodsDinnerSandwichesLunchCasualBBQCocktailsPizzaWine BarSteakDedicated GF MenuBreakfastBrunchDairy Free OptionsKid FriendlyBread ItemsBeerDessertsPastaDeliveryBarOpen Late
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Mark Knight

I'm gluten free and was thrilled that Club Car had a separate GF menu that included a lot of choices. They even had GF soups!!! Fun atmosphere, great service and great food at reasonable prices. We really enjoyed Club Car and definitely will visit again.

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03
Americana

Americana

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Celiac friendly

1312 Locust St, Des Moines, IA 50309, USA

AmericanBrunchGF OptionsAllergen FriendlyBreakfastDairy Free OptionsDeliveryDinnerOpen Late NightLunchTake AwayVegan OptionsVegetarian OptionsDedicated GF FryerCiderDessertsCeliac FriendlyKnowledgeable StaffKid FriendlyPancakesBread ItemsSandwichesCocktails
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Endless food and bottomless mimosas/bloody marys/mixed drinks is a hell of a way to start a weekend. Staff is very friendly and attentive. Food is delicious and there were plenty of options for gluten free eaters.

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04
Fresko

Fresko

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Celiac friendly

909 Locust St Ste. 103, Des Moines, IA 50309, USA

CocktailsBrunchGF OptionsAllergen FriendlyBreakfastDairy Free OptionsDeliveryDinnerKid FriendlyOpen Late NightLunchTake AwayVegan OptionsVegetarian OptionsDedicated GF FryerBread ItemsBurgersDessertsSandwichesTacosCeliac FriendlyRestaurant
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Mijo Martinez (Mijo Martinez)

My chicken chiabatta sandwich was a bit dry and the food selection was limited, but they did have substantial gluten free options. The setting and staff were very nice, making it an overall excellent experience.

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05
Cooper’s Hawk Winery & Restaurants- Clive

Cooper’s Hawk Winery & Restaurants- Clive

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Celiac friendly

12801 University Ave, Clive, IA 50325, USA

Wine BarAmericanGF OptionsBrunchDinnerLunchBread ItemsBurgersDessertsPastaSandwichesKnowledgeable StaffSeparate GF MenuKid FriendlyTake AwayDeliveryCeliac FriendlyOutdoor SeatingDedicated GF Fryer
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Stephanie Dowdy

We ate outside on the patio. Oh my the lettuce wraps are so so good! Excellent service and excellent gluten free menu!

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