The 14 Best Gluten-Free American Restaurants in Des Moines
By Gluten Free Eats' gluten-free community
Updated Jun 2025
Louie's Wine Dive
Celiac friendly
4040 University Ave suite a, Des Moines, IA 50311, USA
A favorite local spot with a vibrant patio and a diverse menu that keeps everyone happy, offering fun shareable bites and tasty drinks.
Americana
Celiac friendly
1312 Locust St, Des Moines, IA 50309, USA
A lively spot with a vast menu and unique stations, perfect for groups but challenging for those with mobility issues due to stair access.
Love it every time. Good atmosphere and I'm pretty find if the gluten sensitive choices. Well worth it.
Buzzard Billy’s
Accommodating
615 3rd St, Des Moines, IA 50309, USA
Unexpectedly fun spot with a lively, sports bar vibe, plus a standout cocktail selection and a variety of delicious menu options.
Had the BEST experience here. Trying to find a restaurant that offers a gluten free menu as well as regular with no discernible differences in taste is 1 in a million and buzzard Billy’s is exactly that. Any time we ever come back it will be good at BB. Kristen, Kela and shiree are the best servers EVER!
Tupelo Honey Southern Kitchen & Bar
Gluten-free options
665 Grand Ave Ste 100, Des Moines, IA 50309, USA
Enjoy a cozy vibe with unique patio space for pups while savoring delicious comfort food that feels like home.
Shrimp and grits, collard greens with bacon...I felt like I was back home. The gluten free options are limited, but they are done well!
Bubba
Gluten-free options
200 10th St, Des Moines, IA 50309, USA
Experience a lively vibe with top-notch Southern dishes and mixed drinks, plus a menu that promises something for everyone!
Went in on a quiet Thursday afternoon and the service and food were top shelf. Ribeye steak was cooked to perfection. Brussels were excellent and the cornbread is actually GLUTEN FREE! Start with the deviled eggs or the street corn dip!
Explore tons of GF spots in Des Moines
and 323k GF places worldwide!
Built with dieticians
Vetted information about every place’s celiac safety
Advanced Filters
Quickly find the exact GF restaurant you are looking for
Celiac community
320K+ reviews and tips by like minded celiacs
I have been using it now for 3 months and it saves me so much research. Reduces the need to call and double check every time.
Kenneth M.
Gluten Intolerant
Finding places to eat used to be such a drag. Atly made it so much easier. Love it!
.png&w=96&q=75){kind=small}
Jane G.
Highly symptomatic celiac
Discover 323k vetted Gluten Free places around the world!
Discover all Des Moines' gluten-free spots
