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The 50 Best Gluten-Free Seafood Spots in South Carolina

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By Gluten Free Eats' gluten-free community

Updated Jul 2025

01
Magnolias

Magnolias

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Celiac friendly

185 E Bay St, Charleston, SC 29401, USA

SeafoodAmericanGF OptionsAllergen FriendlyBrunchDairy Free OptionsDinnerLunchVegan OptionsVegetarian OptionsBeerBread ItemsCeliac FriendlyBreakfastDeliveryTake AwayKid FriendlyRestaurantDedicated GF Fryer
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Amber Easterling

This is always one of my favorite places to visit in Charleston! They have a large gluten-free menu and take any allergies very seriously! The food is always amazing! Lunch or dinner, it’s always so good!

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Dedicated gluten-free menu
02
LuLu's North Myrtle Beach

LuLu's North Myrtle Beach

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Celiac friendly

4954 Hwy 17 S, North Myrtle Beach, SC 29582, USA

GF OptionsSeafoodAllergen FriendlyDairy Free OptionsDinnerKid FriendlyLunchOutdoor SeatingTake AwayVegan OptionsVegetarian OptionsDedicated GF Kitchen SpaceDedicated GF FryerBeerBread ItemsBurgersTacosCeliac FriendlyMexicanDessertsSandwichesDeliveryCasualBreakfastBrunchPet FriendlyBarRestaurant
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Heather Iacono

This place knows about celiac- not just “gluten free”. Extreme care in preparation of food. Separate cooking area and servers! Had the tacos and they were fantastic! The live music was an additional bonus! #celiac

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Dedicated gluten-free menu
03
Skull Creek Dockside

Skull Creek Dockside

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Celiac friendly

2 Hudson Rd, Hilton Head Island, SC 29926, USA

SeafoodGF OptionsAllergen FriendlyBrunchDairy Free OptionsDinnerPet FriendlyKid FriendlyLunchOutdoor SeatingTake AwayVegan OptionsVegetarian OptionsDedicated GF FryerFish & ChipsFriesBurgersBread ItemsPizzaDeliveryCeliac Friendly
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Makayla Deyling

WOW!! LOVE!! came here from Ohio on vacation and will be back before we leave in a week (lol). Paige was amazing, attentive & came back at the perfect times. She offered a gluten free menu to me & manager Chris was HILARIOUS & so kind, would come back just to see Chris. Amazing food and atmosphere.

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Dedicated gluten-free menu
04
Madison's

Madison's

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Celiac friendly

925 10th St, Port Royal, SC 29935, USA

SeafoodGF OptionsAllergen FriendlyDairy Free OptionsDinnerPet FriendlyKid FriendlyLunchOutdoor SeatingTake AwayVegan OptionsVegetarian OptionsBread ItemsBurgersDessertsFriesDeliveryCeliac Friendly
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Kate MacDonald

I love Creole dishes and rarely get to enjoy them since being gluten free due to health reasons. We found Madisons on the gluten free app and are so grateful we did! Madison’s has a very expansive menu of gluten free options including their breaded items (hello crab cakes!). We had a fabulous meal with both the service and food quality being top notch. Madison’s brought so much joy back to dining and was a highlight of our trip to the Beaufort area. Highly recommend!

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05
Villa Romana Italian Restaurant

Villa Romana Italian Restaurant

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Celiac friendly

707 S Kings Hwy, Myrtle Beach, SC 29577, USA

DinnerItalianDeliveryTake AwayKid FriendlyLunchDairy FreePastaVegetarianSeafoodCeliac FriendlyRestaurant
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Heather Iacono

Amazing! Service was terrific and food was absolutely delicious! Celiac friendly- extremely aware and the price was surprisingly very reasonable for the amount of food!! AAA+++

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